The main WP 4 objective is to gather and generate kinetic information for chemicals inducing the six ontologies and thus support quantitative in vitro to in vivo extrapolation (QIVIVE) necessary for chemical risk assessment using NAMs. This main objective is divided into four sub-objectives/tasks: 1) To develop and evaluate in silico models of in vivo distribution kinetics for characterizing ADME; 2) To perform a gap analysis and data mining to evaluate and extend the applicability domain of in silico models for in vitro systems and humans; 3) To develop and evaluate in silico models of in vitro distribution kinetics for estimating cell-associated in vitro effect concentrations for QIVIVE in ADME and qAOP network development; 4) To perform QIVIVE of chemicals associated with ONTOX ontologies for risk assessment.