ONTOX Physiological Maps
Find out more about Physiological Maps and what is their role in the ONTOX project
About The tutorials
ONTOX Tutorials on Physiological Maps
In this series, ONTOX researchers elucidate the concept of Physiological Maps and explain how to use the two main computer tools employed in their development.
Discover importance of physiological maps as emerging frameworks in advancing Next-Generation Risk Assessment. They provide invaluable insights into human physiological mechanisms and toxicological pathways. Our researchers from the University of Liège are working closely with the toxicology and Disease Map Communities to enhance the applicability of Physiological Maps.
You can find out more here.
Video 1: Introduction to Physiological Maps
In this introductory video, Dr. Bernard Staumont, from the Biomechanics Research Unit of the University of Liège, introduces the concept of Physiological Maps, revealing their significance for scientific research and their vital role within the ONTOX project.
Physiological maps can be seen as cartographies that describe in detail biological processes and functions, forming a cornerstone of ONTOX: the biological framework. They are complementary to Adverse Outcome Pathways and represent the first layer of ONTOX ontology maps which aim to integrate biological, chemical and kinetic data, among others.
Video 2: CellDesigner
This video features CellDesigner, presented by Dr. Luiz Ladeira from the University of Liège.
CellDesigner is a practical tool that aids scientists in constructing detailed maps of molecular interactions within our bodies. This introductory tutorial is your gateway to understanding pathway representation and modeling. In the ONTOX project, CellDesigner is crucial in designing Physiological Maps to understand the biological mechanisms that chemicals can perturb.
Video 3: MINERVA platform
In this video, Dr. Alessio Gamba, postdoctoral researcher at the University of Liège, introduces MINERVA, a web-based platform designed to visualize and analyze complex biological networks.
As part of the ONTOX project, MINERVA plays a crucial role in integrating and interpreting large-scale biological data, supporting the development of animal-free toxicity assessment methods. Watch the video to learn more about MINERVA and its features.
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