Through this tutorial series, ONTOX researchers elucidate the concept of Physiological Maps and explain how to use the two main computer tools employed in their development.
Discover their importance as emerging frameworks in advancing Next-Generation Risk Assessment. They provide invaluable insights into human physiological mechanisms and toxicological pathways. Our researchers from the University of Liège are working closely with the toxicology and Disease Map Communities to enhance the applicability of Physiological Maps.
Video 1: Introduction to Physiological Maps
In this introductory video, Dr. Bernard Staumont, senior researcher at the Biomechanics Research Unit of the University of Liège, introduces the concept of Physiological Maps, revealing their significance for scientific research and their vital role within the ONTOX project.
Physiological maps can be seen as cartographies that describe in detail biological processes and functions, forming a cornerstone of ONTOX: the biological framework. They are complementary to Adverse Outcome Pathways and represent the first layer of ONTOX ontology maps which aim to integrate biological, chemical and kinetic data, among others.
Watch the video and find answers to these questions:
- What are the Physiological Maps developed in ONTOX?
- How to build Physiological Maps?
- What do Physiological Maps look like?
- What can Physiological Maps be used for?
Video 2: CellDesigner
The second video features CellDesigner, presented by Dr. Luiz Ladeira from the University of Liège.
Despite its sophisticated name, CellDesigner is a practical tool that aids scientists in constructing detailed maps of molecular interactions within our bodies. This introductory tutorial is your gateway to understanding pathway representation and modeling.
In the ONTOX project, CellDesigner is crucial in designing Physiological Maps to understand the biological mechanisms that chemicals can perturb.
Watch the video and follow the first steps to mastering this tool and starting to construct your own pathways:
Video 3: MINERVA Platform
In this video, Dr. Alessio Gamba, postdoctoral researcher at the University of Liège, introduces MINERVA, a web-based platform designed to visualize and analyze complex biological networks. As part of the ONTOX project, MINERVA plays a crucial role in integrating and interpreting large-scale biological data, supporting the development of animal-free toxicity assessment methods.
Watch the video to learn:
- What is MINERVA, and how does it work?
- How does MINERVA help visualize and analyze complex biological pathways?
- Why is it valuable for the ONTOX project and the future of toxicological research?
Follow the links in the video to discover how the ONTOX project is shaping next generation toxicology by leveraging AI-driven data visualization. Learn how to navigate this information directly in your browser, and don’t hesitate to leave a comment below the video – Alessio will be happy to answer your questions!
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