SCIENTIFIC PAPERS
Find here all scientific publications related to the ONTOX project
Published in 2023
Unraveling the mechanisms underlying drug-induced cholestatic liver injury: identifying key genes using machine learning techniques on human in vitro data sets
Jiang J., van Ertvelde J., Ertaylan G., Peeters R., Jennen D., de Kok T. M., Vinken M.
Archives of Toxicology | August 2023
Optimization of an adverse outcome pathway network on chemical-induced cholestasis using an artificial intelligence-assisted data collection and confidence level quantification approach
van Ertvelde J., Verhoeven A., Maerten A., Cooreman A., Dos Santos Rodrigues B., Sanz-Serrano J., Mihajlovic M., Tripodi I., Teunis M., Jover R., Luechtefeld T., Vanhaecke T., Jiang J., Vinken M.
Journal of Biomedical Informatics | August 2023
Predicting the Mitochondrial Toxicity of Small Molecules: Insights from Mechanistic Assays and Cell Painting Data
Garcia de Lomana M., Marin Zapata P. A., Montanari F.
Chemical Research in Toxicology | July 2023
The effects of hexabromocyclododecane on the transcriptome and hepatic enzyme activity in three human HepaRG-based models
Proença S., van Sabben N., Legler J., Kamstra J. H., Kramer N. I.
Toxicology | February 2023
Published in 2022
Natural language processing in toxicology: Delineating adverse outcome pathways and guiding the application of new approach methodologies
Corradi M., de Haan A., Staumont B., Piersma A., Geris L., Pieters R., Krul C., Teunis M.
Biosystems and Biomaterials | August 2022
Monte Carlo Models for Sub-Chronic Repeated-Dose Toxicity: Systemic and Organ-Specific Toxicity
Selvestrel G., Lavado G. J., Toropova A. P., Toropov A. A., Gadaleta D., Marzo M., Baderna D., Benfenati E.
International Journal of Molecular Sciences | June 2022
Replacement of animal testing by integrated approaches to testing and assessment (IATA): a call for in vivitrosi
Caloni F., De Angelis I., Hartung T.
Archives of Toxicology | May 2022
Mitochondria as the Target of Hepatotoxicity and Drug-Induced Liver Injury: Molecular Mechanisms and Detection Methods
Mihajlovic M., Vinken M.
International Journal of Molecular Sciences | March 2022
Prediction of the Neurotoxic Potential of Chemicals Based on Modelling of Molecular Initiating Events Upstream of the Adverse Outcome Pathways of (Developmental) Neurotoxicity
Gadaleta D., Spînu N., Roncaglioni A., Cronin M. T. D., Benfenati E.
International Journal of Molecular Sciences | March 2022
Scientific Validation of Human Neurosphere Assays for Developmental Neurotoxicity Evaluation
Koch K., Bartmann K., Hartmann J., Kapr J., Klose J., Kuchovská E., Pahl M., Schlüppmann K., Zühr E., Fritsche E.
Frontiers in Toxicology | March 2022
Multi-task Proteochemometric Modelling
Pentina A., Clevert D.-A.
ChemRxiv™ | February 2022
Probabilistic risk assessment – the keystone for the future of toxicology
Maertens A., Golden E., Luechtefeld T. H., Hoffmann S., Tsaioun K., Hartung T.
ALTEX – Alternatives to animal experimentation | January 2022
Published in 2021
Unsupervised Representation Learning for Proteo-chemometric Modeling
Kim P. T., Winter R., Clevert D.-A.
International Journal of Molecular Sciences | December 2021
Img2Mol – accurate SMILES recognition from molecular graphical depictions
Clevert D.-A., Le T., Winter R., Montanari F.
Chemical Science | November 2021
Connexin-Based Channel Activity Is Not Specifically Altered by Hepatocarcinogenic Chemicals
Leroy K., Pieters A., Cooreman A., Van Campenhout R., Cogliati B., Vinken M.
International Journal of Molecular Sciences | October 2021
Protocol for a systematic scoping review
Husøy T., Diemar M. G., Roggen E. L., Kalyva M., Dirven H., Vist G. E.
Methods and tools for assessing chemical exposure in humans (Publication in conference program) | October 2021
Primary Human Hepatocyte Spheroids as Tools to Study the Hepatotoxic Potential of Non-Pharmaceutical Chemicals
Vilas-Boas V., Gijbels E., Leroy K., Pieters A., Baze A., Parmentier C., Vinken M.
International Journal of Molecular Sciences | October 2021
A systematic review of in vitro models of drug-induced kidney injury
Irvine A. R., van Berlo D., Shekhani R., Masereeuw R.
Current Opinion in Toxicology | September 2021
Safer chemicals using less animals: kick-off of the European ONTOX project
Vinken M., Benfenati E., Busquet F., Castell J., Clevert D. A., de Kok T. M., Dirven H., Fritsche E., Geris L., Gozalbes R., Hartung T., Jennen D., Jover R., Kandarova H., Kramer N., Krul C.,
Luechtefeld T., Masereeuw R., Roggen E., Schaller S., Vanhaecke T., Yang Ch., Piersma A. H.
Toxicology | June 2021
In Vitro Liver Toxicity Testing of Chemicals: A Pragmatic Approach
Tabernilla A., dos Santos Rodrigues B., Pieters A., Caufriez A., Leroy K., Van Campenhout R., Cooreman A., Gomes A. R., Arnesdotter E., Gijbels E., Vinken M.
International Journal of Molecular Sciences | May 2021
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