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Check out the latest news from ONTOX! ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
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Welcome to the ONTOX newsletter #14!
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Liesbet Geris granted an Honorary PhD
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The University of Amsterdam has awarded an honorary PhD to Prof. Liesbet Geris, recognising her contributions to the Virtual Human Twin—an innovative computational framework revolutionising biomedical research.
“A digital twin is a computer model of a product, process, or system. It makes predictions that can be used to intervene. In healthcare, this means creating personalised computer models of cells, tissues, or even entire bodies. These models help us understand diseases better and predict the most effective treatments," explains Liesbet.
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Liesbet Geris is a Research Professor in Biomechanics and Computational Tissue Engineering at the University of Liège and KU Leuven in Belgium, the scientific coordinator of the Prometheus – a platform for skeletal tissue engineering, and executive director of the Virtual Physiological Human Institute (VPHi).
As part of the ONTOX project, her work is leading the integration of data, AI, and ontology, developing physiological and ontology maps for key organs, such as the liver, kidney and brain, to assess systemic toxicity.
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#YoungScientist interviews
Anna Rapisarda
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Anna Rapisarda is a Postdoctoral Researcher & Project Manager at the University of Valencia and CIBEREHD.
Anna was motivated to join the ONTOX to get the chance to help reduce the use of animals in chemical risk assessment. She is inspired by ONTOX’s vision to develop reliable, more accurate, ethical alternatives that prioritise human health without relying on animal testing. She finds that contributing to a project that aims to advance toxicology in this way is something significant.
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Bernard Staumont
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Bernard Staumont is a Project Manager & Postdoctoral Researcher at the University of Liège.
Bernard is motivated to work in ONTOX because of the interdisciplinary environment and the opportunity to learn from many experts and work together on developing New Approach Methodologies to reduce animal testing. In ONTOX, Bernard focuses on creating physiological and ontology maps – sophisticated in silico tools visually representing biological processes.
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New ONTOX research papers
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The long way from raw data to NAM-based information: Overview on data layers and processing steps
Blum J., Brüll M., Hengstler J. G., Dietrich D. R., Gruber A. J., Dipalo M., Kraushaar U., Mangas I., Terron A., Fritsche E., Marx-Stoelting P., Hardy B., Schepky A., Escher S., Hartung T., Landsiedel R., Odermatt A., Sachana M., Koch K., Dönmez A., Masjosthusmann S., Bothe K., Schildknecht S., Beilmann M., Beltman J. B., Fitzpatrick S., Mangerich A., Rehm M., Tangianu S., Zickgraf F. M., Kamp H., Burger G., van de Water B., Kleinstreuer N., White A., Leist M.
Alternatives to Animal Experimentation | January 2025
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State of the science on assessing developmental neurotoxicity using new approach methods
Debad S. J., Aungst J., Carstens K., Ferrer M., Fitzpatrick S., Fritsche E., Geng Y., Hartung T., Hogberg H. T., Li R., Mangas I., Marty S., Musser S., Perron M., Rattan S., Rüegg J., Sachana M., Schenke M., Shafer T. J., Smirnova L., Talpos J., Tanguay R. L., Terron A., Bandele O.
Alternatives to Animal Experimentation | January 2025
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Challenges and opportunities for validation of AI-based new approach methods
Hartung T., Kleinstreuer N.
Alternatives to Animal Experimentation | January 2025
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Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: A systematic scoping review
Kalyva M. E., Vist G. E., Diemar M. G., López-Soop G., Bozada T. J., Luechtefeld T., Roggen E. L., Dirven H., Vinken M., Husøy T.
Environmental Pollution | July 2024
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The SOT 64th Annual Meeting and ToxExpo
Meet ONTOX at the US Society of Toxicology (SOT) Annual Meeting 2025! Mark your calendars for 16-20 March 2025 and join us at this prestigious event to explore the latest advancements in toxicology and discuss interesting findings with our researchers. Stay tuned for more updates on ONTOX social media.
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Other project news
ONTOX on PARCopedia
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The knowledge community platform of PARC (European Partnership for the Assessment of Risks from Chemicals) now also comprises information on the ONTOX project. The platform is open to the whole community of professionals in chemical risk assessment.
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ONTOX TV: Work Packages in Action
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In the first video of this new series, Harm Heusinkveld from the National Institute for Public Health and the Environment RIVM, leader of Work Package I on Biological Domain, discusses work on establishing the biological foundation for the ONTOX ontologies.
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ONTOX Impact: Webinars
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Interested in what ONTOX's actual impact on science and society looks like? A newly added website section features expert talks and research advances in next-generation toxicology, providing valuable insights into innovative methods for chemical risk assessment.
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