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ONTOX updates are coming your way! ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏ ͏
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Welcome to the ONTOX newsletter #13!
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ONTOX at EUROTOX 2024
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The Danish Society of Toxicology and Pharmacology hosted the esteemed EUROTOX 2024 congress in Copenhagen, September 8-11, 2024. The event with a theme "Toxicology – A Quest for Safe Chemicals and Medicines," featured a comprehensive and diverse program.
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ONTOX organized a dedicated session titled "Ontology-driven and AI-based Repeated Dose Toxicity Testing Panel," chaired by Nynke Kramer from Wageningen University. The session emphasized innovative research aligned with the 3Rs principle (Replacement, Reduction, Refinement).
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The Early Career Networking Event was a highlight where distinguished experts shared invaluable career insights. Among the panelists was Helena Kandarova, ERT, a pivotal figure in the ONTOX project. She and other panelist discussed the future of toxicology, providing a rare and insightful perspective for attendees.
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ONTOX at ASPIS Open Symposium 2024
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Held in Copenhagen on September 11-12, the event ASPIS OS 2024 showcased key advances in NAMs for chemical safety assessment and fostered collaboration among researchers, regulators, and industry stakeholders.
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The ASPIS cluster, a collaboration of ONTOX, PrecisionTox, and RISK-HUNT3R, is leading the transformation of chemical safety testing. They are developing the ASPIS-initiated Safety Profiling Algorithm (ASPA), an advanced workflow for Next Generation Risk Assessment (NGRA).
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During the symposium, ASPIS cluster leadership transitioned from John Colbourne (PrecisionTox) to Mathieu Vinken (ONTOX), marking a new chapter with ONTOX leading the cluster's mission for sustainable, animal-free chemical risk assessment over the next 18 months.
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Prize Dr. Monique Govaerts and Joseph Lepoix granted to Mathieu Vinken
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Prof. Mathieu Vinken, coordinator of ONTOX and ASPIS, has been awarded the prestigious “Prize Dr. Monique Govaerts and Joseph Lepoix for the study of intoxications” for his research on predicting human safety of chemical compounds, focusing on liver toxicity.
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New ONTOX research papers
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Accessible methods and tools to estimate chemical exposure in humans to support risk assessment: A systematic scoping review
Kalyva M. E., Vist G. E., Diemar M. G., López-Soop G., Bozada T. J., Luechtefeld T., Roggen E. L., Dirven H., Vinken M., Husøy T.
Environmental Pollution | July 2024
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Novel clinical phenotypes, drug categorization, and outcome prediction in drug-induced cholestasis: Analysis of a database of 432 patients developed by literature review and machine learning support
Moreno-Torres M., López-Pascual E., Rapisarda A., Quintás G, Drees A., Steffensen I.L., Luechtefeld T., Serrano-Candelas E., de Lomana M. G., Gadaleta D.,Dirven H., Vinken M., Jover R.
Biomedicine & Pharmacotherapy | May 2024
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Systematic evaluation of high-throughput PBK modelling strategies for the prediction of intravenous and oral pharmacokinetics in humans
Geci R., Gadaleta D., de Lomana M. G,, Ortega-Vallbona R., Colombo E., Serrano-Candelas E., Paini A., Kuepfer L., Schaller S.
Archives of Toxicology | May 2024
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Development of an adverse outcome pathway network for nephrotoxicity
Barnes D. A., Firman J. W., Belfield S. J., Cronin M. T. D., Vinken M., Janssen M. J., Masereeuw R.
Archives of Toxicology | January 2024
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ASPIS Academy at the ESTIV 2024
The ASPIS Academy training session, "Shaping the Future of Chemical Risk Assessment: Insights from ASPIS Academy" took place during 22nd International Congress of the European Society of Toxicology In Vitro (ESTIV 2024. This lunch event on June 4 showcased the significant contributions of Early Stage Researchers (ESRs) from ONTOX, PrecisionTox, and RISK-HUNT3R. The session chaired by Eliška Kuchovská and Luiz Ladeira highlighted how the ASPIS Academy supported the career development of young researchers while furthering the ASPIS cluster's mission of advancing innovative, animal-free chemical risk assessment.
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ASPIS Academy Interviews
The ASPIS Academy launched a new series of career development interviews featuring experts in toxicology and risk assessment. Early-career scientists from the ASPIS cluster engaged with seasoned professionals to explore their motivations and gather advice for aspiring researchers.
In the inaugural interview, Julen Sanz-Serrano (ONTOX) spoke with Mathieu Vinken, ONTOX coordinator and professor at Vrije Universiteit Brussel, about his passion for science and insights to help guide future research journeys.
The second interview in the ASPIS Academy career development series featured Patience Browne, a principal administrator at the OECD. Marie Corradi (ONTOX) discussed the challenges Patience encounters in her role and the passion that drives her work in chemical regulation.
Third interview was with Dylan Underhill, the Head of Public Affairs (UK & EU) at Cruelty Free International, who has dedicated his career to advancing animal protection policies through his work with various NGOs. Eliska Kuchovska (ONTOX) talks with Dylan about his dedication to ending animal testing, the campaigns he’s currently leading, and the crucial role young scientists play in advancing the adoption of NAMs.
Final interview was with Gladys Ouedraogo, an expert from L’Oréal, who shared her experiences in the dynamic cosmetics industry. In a conversation led by Anna Melina Steinbach, an early-career scientist from RISK-HUNT3R, she provided valuable insights and guidance for young researchers considering careers in the field.
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Other project news
ONTOX TV
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Learn more about the ONTOX research and achievements in the new dedicated ONTOX TV. Explore tutorials, interviews with ONTOX scientists and recaps of crucial meetings.
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ONTOX IMPACT website subsection
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Interested in what ONTOX's actual impact on science and society look like? Explore newly added website subsection with ONTOX solutions.
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