27-31 August – WORLD CONGRESS ON ALTERNATIVES AND ANIMAL USE IN THE LIFE SCIENCES WC12 – Niagara Falls, Canada

PRESENTATIONS:

• • Bringing reproducible research and programming skills to the large international research consortium ONTOX; think big – act small
    – presenter: Teunis M. (Hogeschool Utrecht)
  • Going the extra mile for NAM acceptance; Engaging stakeholders for next generation  risk assessment
    – presenter: Krul C. (Hogeschool Utrecht)
  • Mapping of DNT NAMs’ signaling pathways in human physiology and disease
    – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
  • Systems-Biology Modelling of Steatosis and Uncertainty Quantification Towards NGRA
    – presenter: Yang H. (esqLABS GmbH)
  • Towards regulatory acceptance of qAOP-based NGRA through integration with a qualified open-source PBK framework
    – presenter: Schaller S. (esqLABS GmbH)

POSTERS:

• • An adverse outcome pathway network for liver steatosis induced by chemicals
    – presenter: Verhoeven A. (Vrije Universiteit Brussel)
  • Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis
    – presenter: Jian J. (Vrije Universiteit Brussel)
  • Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
    – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

13-17 August – ACS FALL 2023 – San Francisco, USA

PRESENTATION:

• Predicting the mitochondrial toxicity of small molecules: Insights from mechanistic assays and cell painting data
  – presenter: Garcia de Lomana M. (Bayer)
•  

19-21 June – INTERNATIONAL CONFERENCE ON SYSTEMS BIOLOGY OF HUMAN DISEASE – Berlin, Germany

Poster:

• From nephron physiological map to kidney disease ontologies: a systems biology approach for in silico toxicology
  – presenter: Gamba A. (Université de Liège)

7-8 June – NVT ANNUAL MEETING 2023 – Ede, The Netherlands

POSTER:

• • Towards a virtual embryo: Computational modelling of neural tube closure defects
    – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)

31-May-1 June – NEW APPROACH METHODOLOGIES WORKSHOP: TOWARDS AN ANIMAL FREE REGULATORY SYSTEM FOR INDUSTRIAL CHEMICALS – Helsinki, Finland

Presentations:

• Short perspectives on current status and short- to long-term opportunities – Carcinogenity
  – Heusinkveld H. (National Institute for Public Health and the Environment RIVM)
• Short perspectives on current status and short- to long-term opportunities – Developmental and Reproductive Toxicity
  – Piersma A. (National Institute for Public Health and the Environment RIVM)

23-26 May – JRC SUMMER SCHOOL ON NON-ANIMAL APPROACHES IN SCIENCE – Ispra, Italy – ISPRA, ITALY

POSTERS:

• • Next Generation PBK modelling with PK-Sim for the prediction of chemicals distribution in humans
    – presenter: Geci R. (esqLABS GmbH)
  • Physiological maps as a non-animal approach for next-generation risk assessment
    – presenter: Gamba A. (Université de Liège)
  • Update and optimization of an Adverse Outcome Pathway Network of chemical induced cholestasis
    – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

19-23 March – SOT 62nd ANNUAL MEETING AND TOXEXPO – Nashville, USA

Posters:

• A mechanistic and probabilistic PBPK model for amiodarone for quantitative in vitro to in vivo extrapolation
  – presenter: Proença S. (Wageningen University & Research)
• Computational modelling of neural tube closure defects
  – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
• ONTOX Hub meta database bridging AI-based NAMs for Next Generation Risk Assessment 
  – presenter: Mostrag-Szlichtyng A. (Molecular Networks GmbH)

13-14 MARCH – STAKEHOLDER NETWORK MEETING – BRUSSELS, BELGIUM

This first ONTOX Stakeholder meeting, titled “Digging under the surface of ONTOX“, prioritised and addressed specific challenges for the planned Hackathon event (end of 2023/beginning of 2024). The Stakeholder Network meeting was by invitation only.

24-25 NOVEMBER – ASPIS 2nd OPEN SYMPOSIUM – SITGES, SPAIN

Posters:

• A joint voice on the side of NAMs-based strategies for chemical risk assessment: Communication activities 
  – presenter: Kandarova H. and Milec L. (Centre of Experimental Medicine)
• An adverse outcome pathway network for liver steatosis induced by chemicals
  – presenter: Verhoeven A. (Vrije Universiteit Brussel)
• ASPIS Omics Working Group
  – presenter: Caiment F. (Maastricht University)
• Computational modelling of neural tube closure defects
  – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
• Development of an adverse outcome pathway for kidney tubular necrosis
  – presenter: Barnes D. (Universiteit Utrecht)
• Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and pharmacokinetic data gaps within the ONTOX project
  – presenter: Ortega R. (ProtoQSAR)
• In vitro New Approach Methodologies (NAMs) for assessing effects of chemicals leading to cognitive function defects in children – the contributions of the ONTOX project
  – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
• Kinetic modelling and quantitative in vitro-in vivo extrapolation strategies for next generation risk assessment in the H2020 ONTOX project
  – presenter: Geci R. (esqLABS GmbH)
• Physiological maps and chemical-induced disease ontologies: tools to support NAMs development for next-generation risk assessment
  – presenter: Ladeira L. C. M. and Gamba A. (Université de Liège)
• Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
  – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

21-25 November – 21st INTERNATIONAL CONGRESS OF THE ESTIV – Sitges, Spain

PRESENTATION:

• First steps for creating an ontology for cognitive function defects for regulatory application
  – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)

POSTERS:

• An adverse outcome pathway network for liver steatosis induced by chemicals 
  – presenter: Verhoeven A.(Vrije Universiteit Brussel)
• Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis 
  – presenter: Jiang J. (Vrije Universiteit Brussel)
• Computational modelling of neural tube closure defects
  – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
• Designing physiological maps as a tool to study liver toxicology
  – presenter: Ladeira L. C. M. (Université de Liège)
• Development of an adverse outcome pathway for kidney tubular necrosis 
  – presenter: Barnes D. (Universiteit Utrecht)
• Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and toxicokinetic data gaps within the ONTOX project 
  – presenter: Roncaglioni A. (Istituto di Ricerche Farmacologiche Mario Negri)
• Facilitating modern toxicology with natural language processing
  – presenter: Corradi M. (Hogeschool Utrecht)
• PBK modelling of in vivo distribution kinetics in the ONTOX project 
  – presenter: Geci R. (esqLABS GmbH)
• Physiological map to study kidney toxicity in the ONTOX project 
  – presenter: Gamba A. (Université de Liège)
• Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis 
  – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

18-19 October – ECETOC WORKSHOP ON QUANTITATIVE RESPONSE – RESPONSE RELATIONSHIPS (qAOPs) – Brussels, Belgium

presentation:

• Quantitative systems modeling of qAOP and its data integration – ONTOX perspective
  – presenters: Yang H. (esqLABS GmbH)

14-16 October – I LOVE SCIENCE FESTIVAL – Brussels, Belgium

BOOTH:

• Animal-free labs
  – presenters: Belot N., Boige A., Busquet F., Salamone V. (Altertox)

30 SEPTEMBER – The European Researchers’ Night 2022 – Bratislava, Slovakia

BOOTH:

• Toxicology of the 21st century
  – presenters: Kandarova H., Milec L., Pobis P. (Centre of experimental medicine of the Slovak Academy of Sciences) 

29 SEPTEMBER – 3rd In Silico Toxicology Conference 2022 – online

PRESENTATION:

• The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

26-28 SEPTEMBER – The 2022 European Congress on Alternatives to Animal Testing – linz, austria

PRESENTATION:

• The European ONTOX project: safer chemicals using less animals
  – presenter: Vinken M. (Vrije Universiteit Brussel)

22 September – HEARING FLEMISH PARLIAMENT – Virtual

PRESENTATION:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

18-21 September – XVI INTERNATIONAL CONGRESS OF TOXICOLOGY – Maastricht, The Netherlands

12-16 September – EMBL-EBI TRAINING: MATHEMATICS OF LIFE: MODELLING MOLECULAR MECHANISMS – Virtual

6-9 September – VPH 2022 CONFERENCE: VIRTUAL PHYSIOLOGICAL HUMAN – Porto, Portugal

PosterS:

• Developing a physiological map as a framework to study chemical-induced liver steatosis
  – presenter:  Ladeira L. C. M. (Université de Liège)
• From physiological map to ontology unravelling kidney toxicity
  – presenter: Gamba A. (Université de Liège)
• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
• – presenter: Vinken M. (Vrije Universiteit Brussel)

29-30 June – FACE MEETING OF THE LEIBNIZ RESEARCH NETWORK “STEM CELLS AND ORGANOIDS” – Düsseldorf, Germany

Poster:

• First steps for creating an ontology for cognitive function defects for regulatory application
  – presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine)

21-24 June – ONE CONFERENCE 2022 – Brussels, Belgium/Virtual

Posters:

• First steps for creating an ontology for cognitive function deficits for regulatory application
  – presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine)
• Research activities on kinetic modelling and quantitative in vitro–in vivo extrapolation for next generation risk assessment in the H2020 ONTOX project
  – presenter: Paini A. (esqLABS GmbH)
• Use of the Open-Source Software Open Systems Pharmacology Suite (PK-Sim® and MoBi®) in Next Generation Risk Assessment (NGRA)
  – presenter: Schaller S. (esqLABS GmbH)

13-17 JUNE – SUMMER SCHOOL IN BIOINFORMATICS – Hinxton, United Kingdom

Poster:

• From human physiology to toxicity prediction: Working on the ONTOX project
  – presenter: Ladeira L. C. M. (Université de Liège)

27-31 March – The Society of Toxicology 61st Annual Meeting and ToxExpo – USA

Presentation:

• Assessment of Human Neuronal Network Formation and Function Using 2D and 3D hiPSC-Derived Cell Systems
  – presenter: Fritsche E. (IUF – Leibniz Research Institute for Environmental Medicine)
• Computational modeling of (sub)cellular key events in quantitative adverse outcome pathways  towards model-informed human health risk assessment
  – presenter: Schaller S. (esqLABS GmbH)
• Human Neural Tube Defects: Basic Embryology to Predictive Toxicology
  – presenter: Heusinkveld H. (National Institute for Public Health and the Environment RIVM)

14 February – EFSA info session: animal-free next generation risk assessment ready by 2026 – Belgium

Presentation:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

26 January – OECD Working Party on Hazard Assessment – virtual

Presentation:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

18 November – Second international Conference on 3R’S Research and progress – virtual

10 November – The Gates Foundation Grand Challenge meeting – virtual

4 November – ASPIS Kick Off Meeting – Belgium

Presentation:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

22 OCTOBER – Closing event PLANT-UPmeeting – virtual

PRESENTATION:

• 3Rs in EU Policy and Research
  – presenter: Busquet F. (Altertox)

5 October – ILSI Europe annual symposium – The Netherlands

Presentation:

• The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

29 September – EUROTOX – virtual

Presentation:

• Development and application of an adverse outcome pathway of cholestatic liver injury
  – presenter: Vinken M. (Vrije Universiteit Brussel)