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Find the events where we present work related to the ONTOX project

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September 2023
Presentations and posters:
- ASPIS omics group – Steatosis case study
– presenter: Verheijen M. (Universiteit Maastricht) - Going the extra mile for NAM acceptance; Engaging stakeholders for next generation risk assessment
– presenter: Diemar M. G. (3Rs Management and Consulting ApS) - Mapping of DNT NAMs’ signaling pathways in human physiology and disease for regulatory application
– presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine) - Next Generation PBK modeling with PK-Sim for the prediction of chemical distribution in humans
– presenter: Geci R. (esqLABS GmbH) - Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support
– presenter: Lopez-Pascual E. (Universitat de Valencia) - Online methods and tools for assessing chemical exposure in humans: a systematic scoping review for the ONTOX project
– presenter: Kalyva M. (Folkehelseinstituttet) - ONTOX Hub Meta Database paving the way for integrated use of New Approach Methodologies in Next Generation Risk Assessment
– presenter: Mostrag A. (Molecular Networks GmbH) - Probabilistic read-across assessment of 2-MCPD leveraging machine learning and qualified data
– presenter: Rathman J. (Molecular Networks GmbH) - The cognitive function defects ontology: A comprehensive framework for Next-Generation Risk Assessment
– presenter: Ladeira L. (Université de Liège) - The nephron physiological map as a tool to build kidney disease ontologies
– presenter: Gamba A. (Université de Liège) - Towards a virtual embryo: Computational modelling of neural tube closure defects
– presenter: Berkhout J. (Universiteit Utrecht)
Poster:
- Comparison of exposure to PFOS from diet and personal care products with concentrations in blood using a PBPK model – Preliminary results from the EuroMix study as part of the EU project ONTOX
– presenter: Husøy T. (Folkehelseinstituttet)
The ASPIS Open Symposium will follow the 57th Congress of the European Societies of Toxicology, EUROTOX. It will present the latest work of the ASPIS cluster formed by the three Horizon 2020 consortia: ONTOX, PrecisionTox, and RISK-HUNT3R, focusing on the implementation of New Approach Methodologies (NAMs) for chemical risk assessment.
Programme is available on the ASPIS website.
Presentations:
- Introduction to life stage-dependent neurotoxicity, including current status of AOPs
– presenter: Myhre O. (Norwegian Institute of Public Health) - Neurodevelopmental toxicity in the European H2020 ONTOX project
– presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
October 2023
Presentation:
- Novel clinical phenotypes in cholestatic DILI, associated drugs, and new prognosis predictive models: analysis of a database of 432 patients developed by collaborative literature review and machine learning support
– presenter: Lopez-Pascual E. (Universitat de Valencia)
past events
27-31 August – WORLD CONGRESS ON ALTERNATIVES AND ANIMAL USE IN THE LIFE SCIENCES WC12 – Niagara Falls, Canada
PRESENTATIONS:
- Bringing reproducible research and programming skills to the large international research consortium ONTOX; think big – act small
– presenter: Teunis M. (Hogeschool Utrecht) - Going the extra mile for NAM acceptance; Engaging stakeholders for next generation risk assessment
– presenter: Krul C. (Hogeschool Utrecht) - Mapping of DNT NAMs’ signaling pathways in human physiology and disease
– presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine) - Systems-Biology Modelling of Steatosis and Uncertainty Quantification Towards NGRA
– presenter: Yang H. (esqLABS GmbH) - Towards regulatory acceptance of qAOP-based NGRA through integration with a qualified open-source PBK framework
– presenter: Schaller S. (esqLABS GmbH)
- Bringing reproducible research and programming skills to the large international research consortium ONTOX; think big – act small
POSTERS:
- An adverse outcome pathway network for liver steatosis induced by chemicals
– presenter: Verhoeven A. (Vrije Universiteit Brussel) - Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis
– presenter: Jian J. (Vrije Universiteit Brussel) - Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
– presenter: van Ertvelde J. (Vrije Universiteit Brussel)
- An adverse outcome pathway network for liver steatosis induced by chemicals
13-17 August – ACS FALL 2023 – San Francisco, USA
PRESENTATION:
- Predicting the mitochondrial toxicity of small molecules: Insights from mechanistic assays and cell painting data
– presenter: Garcia de Lomana M. (Bayer)
19-21 June – INTERNATIONAL CONFERENCE ON SYSTEMS BIOLOGY OF HUMAN DISEASE – Berlin, Germany
Poster:
- From nephron physiological map to kidney disease ontologies: a systems biology approach for in silico toxicology
– presenter: Gamba A. (Université de Liège)
7-8 June – NVT ANNUAL MEETING 2023 – Ede, The Netherlands
POSTER:
-
- Towards a virtual embryo: Computational modelling of neural tube closure defects
– presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
- Towards a virtual embryo: Computational modelling of neural tube closure defects
31-May-1 June – NEW APPROACH METHODOLOGIES WORKSHOP: TOWARDS AN ANIMAL FREE REGULATORY SYSTEM FOR INDUSTRIAL CHEMICALS – Helsinki, Finland
Presentations:
- Short perspectives on current status and short- to long-term opportunities – Carcinogenity
– Heusinkveld H. (National Institute for Public Health and the Environment RIVM) - Short perspectives on current status and short- to long-term opportunities – Developmental and Reproductive Toxicity
– Piersma A. (National Institute for Public Health and the Environment RIVM)
Participation:
- Vinken M. (Vrije Universiteit Brussel), Roggen E. L. (3Rs Management and Consulting ApS)
23-26 May – JRC SUMMER SCHOOL ON NON-ANIMAL APPROACHES IN SCIENCE – Ispra, Italy – ISPRA, ITALY
POSTERS:
- Next Generation PBK modelling with PK-Sim for the prediction of chemicals distribution in humans
– presenter: Geci R. (esqLABS GmbH) - Physiological maps as a non-animal approach for next-generation risk assessment
– presenter: Gamba A. (Université de Liège) - Update and optimization of an Adverse Outcome Pathway Network of chemical induced cholestasis
– presenter: van Ertvelde J. (Vrije Universiteit Brussel)
- Next Generation PBK modelling with PK-Sim for the prediction of chemicals distribution in humans
19-23 March – SOT 62nd ANNUAL MEETING AND TOXEXPO – Nashville, USA
Posters:
- A mechanistic and probabilistic PBPK model for amiodarone for quantitative in vitro to in vivo extrapolation
– presenter: Proença S. (Wageningen University & Research) - Computational modelling of neural tube closure defects
– presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM) - ONTOX Hub meta database bridging AI-based NAMs for Next Generation Risk Assessment
– presenter: Mostrag-Szlichtyng A. (Molecular Networks GmbH)
BOOTH:
- ASPIS cluster booth 1435 in the #ToxExpo Exhibit Hall
– ONTOX consortium was presented in the ASPIS cluster booth.
13-14 MARCH – STAKEHOLDER NETWORK MEETING – BRUSSELS, BELGIUM
This first ONTOX Stakeholder meeting, titled “Digging under the surface of ONTOX“, prioritised and addressed specific challenges for the planned Hackathon event (end of 2023/beginning of 2024). The Stakeholder Network meeting was by invitation only.
24-25 NOVEMBER – ASPIS 2nd OPEN SYMPOSIUM – SITGES, SPAIN
Posters:
- A joint voice on the side of NAMs-based strategies for chemical risk assessment: Communication activities
– presenter: Kandarova H. and Milec L. (Centre of Experimental Medicine) - An adverse outcome pathway network for liver steatosis induced by chemicals
– presenter: Verhoeven A. (Vrije Universiteit Brussel) - ASPIS Omics Working Group
– presenter: Caiment F. (Maastricht University) - Computational modelling of neural tube closure defects
– presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM) - Development of an adverse outcome pathway for kidney tubular necrosis
– presenter: Barnes D. (Universiteit Utrecht) - Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and pharmacokinetic data gaps within the ONTOX project
– presenter: Ortega R. (ProtoQSAR) - In vitro New Approach Methodologies (NAMs) for assessing effects of chemicals leading to cognitive function defects in children – the contributions of the ONTOX project
– presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine) - Kinetic modelling and quantitative in vitro-in vivo extrapolation strategies for next generation risk assessment in the H2020 ONTOX project
– presenter: Geci R. (esqLABS GmbH) - Physiological maps and chemical-induced disease ontologies: tools to support NAMs development for next-generation risk assessment
– presenter: Ladeira L. C. M. and Gamba A. (Université de Liège) - Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
– presenter: van Ertvelde J. (Vrije Universiteit Brussel)
21-25 November – 21st INTERNATIONAL CONGRESS OF THE ESTIV – Sitges, Spain
PRESENTATION:
- First steps for creating an ontology for cognitive function defects for regulatory application
– presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
POSTERS:
- An adverse outcome pathway network for liver steatosis induced by chemicals
– presenter: Verhoeven A.(Vrije Universiteit Brussel) - Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis
– presenter: Jiang J. (Vrije Universiteit Brussel) - Computational modelling of neural tube closure defects
– presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM) - Designing physiological maps as a tool to study liver toxicology
– presenter: Ladeira L. C. M. (Université de Liège) - Development of an adverse outcome pathway for kidney tubular necrosis
– presenter: Barnes D. (Universiteit Utrecht) - Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and toxicokinetic data gaps within the ONTOX project
– presenter: Roncaglioni A. (Istituto di Ricerche Farmacologiche Mario Negri) - Facilitating modern toxicology with natural language processing
– presenter: Corradi M. (Hogeschool Utrecht) - PBK modelling of in vivo distribution kinetics in the ONTOX project
– presenter: Geci R. (esqLABS GmbH) - Physiological map to study kidney toxicity in the ONTOX project
– presenter: Gamba A. (Université de Liège) - Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
– presenter: van Ertvelde J. (Vrije Universiteit Brussel)
18-19 October – ECETOC WORKSHOP ON QUANTITATIVE RESPONSE – RESPONSE RELATIONSHIPS (qAOPs) – Brussels, Belgium
presentation:
- Quantitative systems modeling of qAOP and its data integration – ONTOX perspective
– presenters: Yang H. (esqLABS GmbH)
14-16 October – I LOVE SCIENCE FESTIVAL – Brussels, Belgium
BOOTH:
- Animal-free labs
– presenters: Belot N., Boige A., Busquet F., Salamone V. (Altertox)
30 SEPTEMBER – The European Researchers’ Night 2022 – Bratislava, Slovakia
BOOTH:
- Toxicology of the 21st century
– presenters: Kandarova H., Milec L., Pobis P. (Centre of experimental medicine of the Slovak Academy of Sciences)
29 SEPTEMBER – 3rd In Silico Toxicology Conference 2022 – online
PRESENTATION:
- The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
– presenter: Vinken M. (Vrije Universiteit Brussel)
26-28 SEPTEMBER – The 2022 European Congress on Alternatives to Animal Testing – linz, austria
PRESENTATION:
- The European ONTOX project: safer chemicals using less animals
– presenter: Vinken M. (Vrije Universiteit Brussel)
22 September – HEARING FLEMISH PARLIAMENT – Virtual
PRESENTATION:
- ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
– presenter: Vinken M. (Vrije Universiteit Brussel)
18-21 September – XVI INTERNATIONAL CONGRESS OF TOXICOLOGY – Maastricht, The Netherlands
POSTERs:
- A knowledge hub leveraging public resources to improve in silico chemical safety assessment
– presenter: Marusczyk J. (Molecular Networks GmbH) - Computational modelling of neural tube closure defects
– presenter: Berkhout J. (Universiteit Utrecht) - Development of an adverse outcome pathway for kidney tubular necrosis
– presenter: Barnes D. (Universiteit Utrecht) - New approaches for evaluating kidney toxicity using physiological maps
– presenter: Gamba A. (Université de Liège) - Physiology-based framework to study chemical-induced cholestasis
– presenter: Ladeira L. C. M. (Université de Liège)
PRESENTATIONs:
- Artificial intelligence and open science to build adverse outcome pathways and perform toxicological risk assessment
– presenter: Teunis M. (Hogeschool Utrecht) - First steps for creating an ontology for cognitive function defects for regulatory application
– presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine) - Characterising applicability domains of generic in vitro distribution kinetic and physiologically based kinetic models
– presenter: Kramer N. (Wageningen University & Research) - In silico testing
– presenter: Yang. Ch. (Molecular Networks GmbH) - Physiological maps: a benchmark tool for adverse outcome pathways and a cornerstone for the development of disease ontologies
– presenter: Staumont B. (Université de Liège) - Testing of chemicals for next generation risk assessment
– presenter: Vinken M. (Vrije Universiteit Brussel) - The artificial intelligence pillar
– presenter: Hartung T. (Johns Hopkins University Center for Alternatives to Animal Testing) - The ontology pillar
– presenter: Piersma A. (National Institute for Public Health and the Environment RIVM)
12-16 September – EMBL-EBI TRAINING: MATHEMATICS OF LIFE: MODELLING MOLECULAR MECHANISMS – Virtual
POSTER:
- Physiological maps and ontologies to study toxicities
– presenter: Gamba A. (Université de Liège)
12-16 September – OPENTOX 2022 VIRTUAL CONFERENCE – Virtual
Presentation:
- Toward probabilistic risk assessment – the ONTOX project
– presenter: Hartung T. (Johns Hopkins University Center for Alternatives to Animal Testing)
6-9 September – VPH 2022 CONFERENCE: VIRTUAL PHYSIOLOGICAL HUMAN – Porto, Portugal
PosterS:
- Developing a physiological map as a framework to study chemical-induced liver steatosis
– presenter: Ladeira L. C. M. (Université de Liège) - From physiological map to ontology unravelling kidney toxicity
– presenter: Gamba A. (Université de Liège) - ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
- – presenter: Vinken M. (Vrije Universiteit Brussel)
29-30 June – FACE MEETING OF THE LEIBNIZ RESEARCH NETWORK “STEM CELLS AND ORGANOIDS” – Düsseldorf, Germany
Poster:
- First steps for creating an ontology for cognitive function defects for regulatory application
– presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine)
21-24 June – ONE CONFERENCE 2022 – Brussels, Belgium/Virtual
Posters:
- First steps for creating an ontology for cognitive function deficits for regulatory application
– presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine) - Research activities on kinetic modelling and quantitative in vitro–in vivo extrapolation for next generation risk assessment in the H2020 ONTOX project
– presenter: Paini A. (esqLABS GmbH) - Use of the Open-Source Software Open Systems Pharmacology Suite (PK-Sim® and MoBi®) in Next Generation Risk Assessment (NGRA)
– presenter: Schaller S. (esqLABS GmbH)
13-17 JUNE – SUMMER SCHOOL IN BIOINFORMATICS – Hinxton, United Kingdom
Poster:
- From human physiology to toxicity prediction: Working on the ONTOX project
– presenter: Ladeira L. C. M. (Université de Liège)
27-31 March – The Society of Toxicology 61st Annual Meeting and ToxExpo – USA
Presentation:
- Assessment of Human Neuronal Network Formation and Function Using 2D and 3D hiPSC-Derived Cell Systems
– presenter: Fritsche E. (IUF – Leibniz Research Institute for Environmental Medicine) - Computational modeling of (sub)cellular key events in quantitative adverse outcome pathways towards model-informed human health risk assessment
– presenter: Schaller S. (esqLABS GmbH) - Human Neural Tube Defects: Basic Embryology to Predictive Toxicology
– presenter: Heusinkveld H. (National Institute for Public Health and the Environment RIVM)
14 February – EFSA info session: animal-free next generation risk assessment ready by 2026 – Belgium
Presentation:
- ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
– presenter: Vinken M. (Vrije Universiteit Brussel)
26 January – OECD Working Party on Hazard Assessment – virtual
Presentation:
- ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
– presenter: Vinken M. (Vrije Universiteit Brussel)
18 November – Second international Conference on 3R’S Research and progress – virtual
PRESENTATION:
- presenter: Vinken M. (Vrije Universiteit Brussel)
11 NOVEMBER – Nordic Training on New Approach Methodologies – Norway
PRESENTATION:
- The ONTOX project
– presenter: Dirven H. (Norwegian Institute of Public Health)
10 November – The Gates Foundation Grand Challenge meeting – virtual
PRESENTATION:
- Artificial intelligence
– presenter: Hartung T. (Johns Hopkins University Center for Alternatives to Animal Testing)
4 November – ASPIS Kick Off Meeting – Belgium
Presentation:
- ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
– presenter: Vinken M. (Vrije Universiteit Brussel)
22 OCTOBER – Closing event PLANT-UPmeeting – virtual
PRESENTATION:
- 3Rs in EU Policy and Research
– presenter: Busquet F. (Altertox)
5 October – ILSI Europe annual symposium – The Netherlands
Presentation:
- The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
– presenter: Vinken M. (Vrije Universiteit Brussel)
29 September – EUROTOX – virtual
Presentation:
- Development and application of an adverse outcome pathway of cholestatic liver injury
– presenter: Vinken M. (Vrije Universiteit Brussel)
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