meet us

Find the events where we present work related to the ONTOX project

upcoming events

May 2023

POSTERs:
    • Next Generation PBK modelling with PK-Sim for the prediction of chemicals distribution in humans
      – presenter: Geci R. (esqLABS GmbH)
    • Physiological maps as a non-animal approach for next-generation risk assessment
      – presenter: Gamba A. (Université de Liège)
Presentations:
    • Short perspectives on current status and short- to long-term opportunities – Carcinogenity
      – Heusinkveld H. (National Institute for Public Health and the Environment RIVM)
    • Short perspectives on current status and short- to long-term opportunities – Developmental and Reproductive Toxicity
      – Piersma A. (National Institute for Public Health and the Environment RIVM)
Participation:
    • Vinken M. (Vrije Universiteit Brussel), Roggen E. L. (3Rs Management and Consulting ApS)

june 2023

Poster:
    • Towards a virtual embryo: Computational modelling of neural tube closure defects
      – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
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Poster:
    • From nephron physiological map to kidney disease ontologies: a systems biology approach for in silico toxicology
      – presenter: Gamba A. (Université de Liège)
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August 2023

Presentation:
    • Predicting the mitochondrial toxicity of small molecules: Insights from mechanistic assays and cell painting data
      – presenter: Garcia de Lomana M. (Bayer)
Presentations:
    • Bringing reproducible research and programming skills to the large international research consortium ONTOX; think big – act small
      – presenter: Teunis M. (Hogeschool Utrecht)
    • Going the extra mile for NAM acceptance; Engaging stakeholders for next generation  risk assessment
      – presenter: Krul C. (Hogeschool Utrecht)
    • Mapping of DNT NAMs’ signaling pathways in human physiology and disease
      – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
    • Systems-Biology Modelling of Steatosis and Uncertainty Quantification Towards NGRA
      – presenter: Yang H. (esqLABS GmbH)
    • Towards regulatory acceptance of qAOP-based NGRA through integration with a qualified open-source PBK framework
      – presenter: Schaller S. (esqLABS GmbH)
POSTERs:
    • An adverse outcome pathway network for liver steatosis induced by chemicals
      – presenter: Verhoeven A. (Vrije Universiteit Brussel)
    • Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis
      – presenter: Jian J. (Vrije Universiteit Brussel)
    • Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
      – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

September 2023

Presentations and posters:
  • ASPIS omics group – Steatosis case study
    – presenter: Verheijen M. (Universiteit Maastricht)
  • Mapping of DNT NAMs’ signaling pathways in human physiology and disease for regulatory application
    – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
  • Next Generation PBK modeling with PK-Sim for the prediction of chemical distribution in humans
    – presenter: Geci R. (esqLABS GmbH)
  • Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support
    – presenter: Lopez-Pascual E. (Universitat de Valencia)
  • Online methods and tools for assessing chemical exposure in humans: a systematic scoping review for the ONTOX project
    – presenter: Kalyva M. (Folkehelseinstituttet)
  • ONTOX Hub Meta Database paving the way for integrated use of New Approach Methodologies in Next Generation Risk Assessment
    – presenter: Mostrag A. (Molecular Networks GmbH)
  • Probabilistic read-across assessment of 2-MCPD leveraging machine learning and qualified data
    – presenter: Rathman J. (Molecular Networks GmbH)
  • The cognitive function defects ontology: A comprehensive framework for Next-Generation Risk Assessment
    – presenter: Ladeira L. (Université de Liège)
  • The nephron physiological map as a tool to build kidney disease ontologies
    – presenter: Gamba A. (Université de Liège)
  • Towards a virtual embryo: Computational modelling of neural tube closure defects
    – presenter: Berkhout J. (Universiteit Utrecht)
Poster:
  • Comparison of exposure to PFOS from diet and personal care products with concentrations in blood using a PBPK model – Preliminary results from the EuroMix study as part of the EU project ONTOX
    – presenter: Husøy T. (Folkehelseinstituttet)
The third ASPIS Open Symposium in 2023 will be held on 14-15 September 2023 in Ljubljana, Slovenia, at the GR – Ljubljana Exhibition and Convention Centre.
 
More information on program will follow soon.

past events

19-23 March – SOT 62nd ANNUAL MEETING AND TOXEXPO – Nashville, USA

Posters:

  • A mechanistic and probabilistic PBPK model for amiodarone for quantitative in vitro to in vivo extrapolation
    – presenter: Proença S. (Wageningen University & Research)
  • Computational modelling of neural tube closure defects
    – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
  • ONTOX Hub meta database bridging AI-based NAMs for Next Generation Risk Assessment 
    – presenter: Mostrag-Szlichtyng A. (Molecular Networks GmbH)
BOOTH:
  • ASPIS cluster booth 1435 in the #ToxExpo Exhibit Hall
    – ONTOX consortium was presented in the ASPIS cluster booth. 
13-14 MARCH – STAKEHOLDER NETWORK MEETING – BRUSSELS, BELGIUM

This first ONTOX Stakeholder meeting, titled “Digging under the surface of ONTOX“, prioritised and addressed specific challenges for the planned Hackathon event (end of 2023/beginning of 2024). The Stakeholder Network meeting was by invitation only.

24-25 NOVEMBER – ASPIS 2nd OPEN SYMPOSIUM – SITGES, SPAIN

Posters:

  • A joint voice on the side of NAMs-based strategies for chemical risk assessment: Communication activities 
    – presenter: Kandarova H. and Milec L. (Centre of Experimental Medicine)
  • An adverse outcome pathway network for liver steatosis induced by chemicals
    – presenter: Verhoeven A. (Vrije Universiteit Brussel)
  • ASPIS Omics Working Group
    – presenter: Caiment F. (Maastricht University)
  • Computational modelling of neural tube closure defects
    – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
  • Development of an adverse outcome pathway for kidney tubular necrosis
    – presenter: Barnes D. (Universiteit Utrecht)
  • Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and pharmacokinetic data gaps within the ONTOX project
    – presenter: Ortega R. (ProtoQSAR)
  • In vitro New Approach Methodologies (NAMs) for assessing effects of chemicals leading to cognitive function defects in children – the contributions of the ONTOX project
    – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
  • Kinetic modelling and quantitative in vitro-in vivo extrapolation strategies for next generation risk assessment in the H2020 ONTOX project
    – presenter: Geci R. (esqLABS GmbH)
  • Physiological maps and chemical-induced disease ontologies: tools to support NAMs development for next-generation risk assessment
    – presenter: Ladeira L. C. M. and Gamba A. (Université de Liège)
  • Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
    – presenter: van Ertvelde J. (Vrije Universiteit Brussel)
21-25 November – 21st INTERNATIONAL CONGRESS OF THE ESTIV – Sitges, Spain
PRESENTATION:
  • First steps for creating an ontology for cognitive function defects for regulatory application
    – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
POSTERS:
  • An adverse outcome pathway network for liver steatosis induced by chemicals 
    – presenter: Verhoeven A.(Vrije Universiteit Brussel)
  • Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis 
    – presenter: Jiang J. (Vrije Universiteit Brussel)
  • Computational modelling of neural tube closure defects
    – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
  • Designing physiological maps as a tool to study liver toxicology
    – presenter: Ladeira L. C. M. (Université de Liège)
  • Development of an adverse outcome pathway for kidney tubular necrosis 
    – presenter: Barnes D. (Universiteit Utrecht)
  • Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and toxicokinetic data gaps within the ONTOX project 
    – presenter: Roncaglioni A. (Istituto di Ricerche Farmacologiche Mario Negri)
  • Facilitating modern toxicology with natural language processing
    – presenter: Corradi M. (Hogeschool Utrecht)
  • PBK modelling of in vivo distribution kinetics in the ONTOX project 
    – presenter: Geci R. (esqLABS GmbH)
  • Physiological map to study kidney toxicity in the ONTOX project 
    – presenter: Gamba A. (Université de Liège)
  • Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis 
    – presenter: van Ertvelde J. (Vrije Universiteit Brussel)
18-19 October – ECETOC WORKSHOP ON QUANTITATIVE RESPONSE – RESPONSE RELATIONSHIPS (qAOPs) – Brussels, Belgium
presentation:
  • Quantitative systems modeling of qAOP and its data integration – ONTOX perspective
    – presenters: Yang H. (esqLABS GmbH)
14-16 October – I LOVE SCIENCE FESTIVAL – Brussels, Belgium
BOOTH:
  • Animal-free labs
    – presenters: Belot N., Boige A., Busquet F., Salamone V. (Altertox)
30 SEPTEMBER – The European Researchers’ Night 2022 – Bratislava, Slovakia
BOOTH:
  • Toxicology of the 21st century
    – presenters: Kandarova H., Milec L., Pobis P. (Centre of experimental medicine of the Slovak Academy of Sciences) 
29 SEPTEMBER – 3rd In Silico Toxicology Conference 2022 – online
PRESENTATION:
  • The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
    – presenter: Vinken M. (Vrije Universiteit Brussel)
26-28 SEPTEMBER – The 2022 European Congress on Alternatives to Animal Testing – linz, austria
PRESENTATION:
  • The European ONTOX project: safer chemicals using less animals
    – presenter: Vinken M. (Vrije Universiteit Brussel)
22 September – HEARING FLEMISH PARLIAMENT – Virtual
PRESENTATION:
  • ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
    – presenter: Vinken M. (Vrije Universiteit Brussel)
18-21 September – XVI INTERNATIONAL CONGRESS OF TOXICOLOGY – Maastricht, The Netherlands
POSTERs:
  • A knowledge hub leveraging public resources to improve in silico chemical safety assessment
    – presenter: Marusczyk J. (Molecular Networks GmbH)
  • Computational modelling of neural tube closure defects
    – presenter: Berkhout J. (Universiteit Utrecht)
  • Development of an adverse outcome pathway for kidney tubular necrosis
    – presenter: Barnes D. (Universiteit Utrecht)
  • New approaches for evaluating kidney toxicity using physiological maps
    – presenter: Gamba A. (Université de Liège)
  • Physiology-based framework to study chemical-induced cholestasis
    – presenter: Ladeira L. C. M. (Université de Liège)
PRESENTATIONs:
  • Artificial intelligence and open science to build adverse outcome pathways and perform toxicological risk assessment
    – presenter: Teunis M. (Hogeschool Utrecht)
  • First steps for creating an ontology for cognitive function defects for regulatory application
    – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
  • Characterising applicability domains of generic in vitro distribution kinetic and physiologically based kinetic models
    – presenter: Kramer N. (Wageningen University & Research)
  • In silico testing
    – presenter: Yang. Ch. (Molecular Networks GmbH)
  • Physiological maps: a benchmark tool for adverse outcome pathways and a cornerstone for the development of disease ontologies 
    – presenter: Staumont B. (Université de Liège)
  • Testing of chemicals for next generation risk assessment
    – presenter: Vinken M. (Vrije Universiteit Brussel)
  • The artificial intelligence pillar
    – presenter: Hartung T. (Johns Hopkins University Center for Alternatives to Animal Testing)
  • The ontology pillar
    – presenter: Piersma A. (National Institute for Public Health and the Environment RIVM)
12-16 September – EMBL-EBI TRAINING: MATHEMATICS OF LIFE: MODELLING MOLECULAR MECHANISMS – Virtual
POSTER:
  • Physiological maps and ontologies to study toxicities
    – presenter: Gamba A. (Université de Liège)
12-16 September – OPENTOX 2022 VIRTUAL CONFERENCE – Virtual
Presentation:
  • Toward probabilistic risk assessment – the ONTOX project
    – presenter: Hartung T. (Johns Hopkins University Center for Alternatives to Animal Testing)
6-9 September – VPH 2022 CONFERENCE: VIRTUAL PHYSIOLOGICAL HUMAN – Porto, Portugal
PosterS:
  • Developing a physiological map as a framework to study chemical-induced liver steatosis
    – presenter:  Ladeira L. C. M. (Université de Liège)
  • From physiological map to ontology unravelling kidney toxicity
    – presenter: Gamba A. (Université de Liège)
  • ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  • – presenter: Vinken M. (Vrije Universiteit Brussel)
29-30 June – FACE MEETING OF THE LEIBNIZ RESEARCH NETWORK “STEM CELLS AND ORGANOIDS” – Düsseldorf, Germany
Poster:
  • First steps for creating an ontology for cognitive function defects for regulatory application
    – presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine)
21-24 June – ONE CONFERENCE 2022 – Brussels, Belgium/Virtual
Posters:
  • First steps for creating an ontology for cognitive function deficits for regulatory application
    – presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine)
  • Research activities on kinetic modelling and quantitative in vitro–in vivo extrapolation for next generation risk assessment in the H2020 ONTOX project
    – presenter: Paini A. (esqLABS GmbH)
  • Use of the Open-Source Software Open Systems Pharmacology Suite (PK-Sim® and MoBi®) in Next Generation Risk Assessment (NGRA)
    – presenter: Schaller S. (esqLABS GmbH)
13-17 JUNE – SUMMER SCHOOL IN BIOINFORMATICS – Hinxton, United Kingdom
Poster:
  • From human physiology to toxicity prediction: Working on the ONTOX project
    – presenter: Ladeira L. C. M. (Université de Liège)
27-31 March – The Society of Toxicology 61st Annual Meeting and ToxExpo – USA
Presentation:
  • Assessment of Human Neuronal Network Formation and Function Using 2D and 3D hiPSC-Derived Cell Systems
    – presenter: Fritsche E. (IUF – Leibniz Research Institute for Environmental Medicine)
  • Computational modeling of (sub)cellular key events in quantitative adverse outcome pathways  towards model-informed human health risk assessment
    – presenter: Schaller S. (esqLABS GmbH)
  • Human Neural Tube Defects: Basic Embryology to Predictive Toxicology
    – presenter: Heusinkveld H. (National Institute for Public Health and the Environment RIVM)
14 February – EFSA info session: animal-free next generation risk assessment ready by 2026 – Belgium
Presentation:
  • ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
    – presenter: Vinken M. (Vrije Universiteit Brussel)
26 January – OECD Working Party on Hazard Assessment – virtual
Presentation:
  • ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
    – presenter: Vinken M. (Vrije Universiteit Brussel)
18 November – Second international Conference on 3R’S Research and progress – virtual
PRESENTATION:
  • presenter: Vinken M. (Vrije Universiteit Brussel)
11 NOVEMBER – Nordic Training on New Approach Methodologies – Norway
PRESENTATION:
  • The ONTOX project
    – presenter: Dirven H. (Norwegian Institute of Public Health)
10 November – The Gates Foundation Grand Challenge meeting – virtual
PRESENTATION:
  • Artificial intelligence
    – presenter: Hartung T. (Johns Hopkins University Center for Alternatives to Animal Testing)
4 November – ASPIS Kick Off Meeting – Belgium
Presentation:
  • ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
    – presenter: Vinken M. (Vrije Universiteit Brussel)
22 OCTOBER – Closing event PLANT-UPmeeting – virtual
PRESENTATION:
  • 3Rs in EU Policy and Research
    – presenter: Busquet F. (Altertox)
5 October – ILSI Europe annual symposium – The Netherlands
Presentation:
  • The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
    – presenter: Vinken M. (Vrije Universiteit Brussel)
29 September – EUROTOX – virtual
Presentation:
  • Development and application of an adverse outcome pathway of cholestatic liver injury
    – presenter: Vinken M. (Vrije Universiteit Brussel)