14-17 September 2025 – 59th EUROTOX 2025 | Athens, Greece

Presentations:

• In vitro/in silico integrative test battery to detect adverse outcome pathway anchored events of chemical-induced cholestatic liver toxicity
  – presenter: Drees, A. (VUB)
• The use of natural language processing in toxicology
  – presenter: Corradi, M. (HU)
• AnthroDrugs-EDC: personalized EDC toxicology through population genetics
  – presenter: Perera del Rosario, S. (PROTO) 

Posters:

• Regulation of key neurodevelopmental processes by disease pathways and nuclear receptors in a human Neurosphere Assay
  – presenter: Kuchovská, E. (IUF) 
• Evaluation of Inhalation and Gastrointestinal Toxicity of Novel Benzoazepine Derivatives with Potential Therapeutic Effects for the Treatment of COVID-19 and Post-COVID Syndrome
  – presenter: Pôbiš, P. (CEM)
• Development and Internal Evaluation of an Ocular Photoirritation Testing Strategy Using a Battery of In Silico and In Vitro Methods
  – presenter: Kanďárová, H. (CEM)
• In vitro/in silico integrative test battery to detect adverse outcome pathway anchored events of chemical-induced cholestatic liver toxicity
  – presenter: Gozalbes, R. (PROTO)
• Unraveling drug-induced hepatic steatosis: clinical sub-phenotypes, prognosis prediction and identification of high-concern drugs and hazardous chemical attributes
  – presenter: Jover, R. (UV)

8 April 2025 – ONTOX-VHP4S webinar | ZOOM, online

Presentations:

• The European ONTOX Project: Ontology-Driven and Artificial Intelligence-Based Repeated Dose Toxicity Testing of Chemicals for Next Generation Risk Assessment
  – presenter: Diemar, M. G. (3RSMC)

16-20 March 2025– the SOT 64th annual meeting and toxexpo – Florida, USA

Presentations:

• Development of an In Vitro Battery for Predicting Nephrotoxicity: Elucidating Early Onset Mechanisms of Kidney Toxicity
  – presenter: Barnes, D. (UU)
• Toward a Virtual Embryo: A Dynamic Systems Model for the Prediction of Neural Tube Closure Defects
  – presenter: Berkhout, J. (UU)
• Machine learning classification of steatogenic compounds using toxicogenomics profiles
  – presenter: Bwanya, B. (UM TGX)
• ’Omics Data and Regulatory Frameworks: Success and Challenges 
  – presenter: Caiment, F. (UM TGX)
• The Use of AI in Safety Assessment of Medical Devices
  – presenter: Hartung, T. (JHSPH)
• Occular irritation and photo-irritation testing of medical devices and drugs using 3D human reconstructed cornea-like tissue model
  – presenter: Kandarova, H. (CEM)
• A Framework for Improving the Quality of In Vitro Toxicity Data for Quantitative In Vitro to In Vivo Extrapolation of “Difficult” Chemicals
  – presenter: Kramer, N. (WU)
• Integrating In Vitro Biokinetics Tools into Next-Generation Risk Assessment Using the ASPA Workflow
  – presenter: Kramer, N. (WU)
• Biocompatibility testing of intraoral medical devices using in vitro 3D reconstructed human oral tissue model
  – presenter: Pôbiš, P. (CEM)
• Advancing Maternal-Fetal PBK Models for Cross-Species Risk Assessment in Toxicology
  – presenter: Siccardi, M. (ESQ)
• An EU strategy on aggregate exposure: The ExpoAdvance Roadmap
  – presenter: Siccardi, M. (ESQ)
• Purrfect fit: Validation of PK-Sim cat model for iv administration
  – presenter: Siccardi, M. (ESQ)
• Building Knowledge: Ontology Maps for Applications in Toxicology
  – presenter: Staumont, B. (UL)
• Effects of Altered Microgravity and Cosmic Radiation on the Liver
  – presenter: Vinken, M. (VUB)

Exhibitors:

• ONTOX, PrecisionTox, RISK-HUNT3R – the members of the ASPIS cluster
  – booth #1362
• Jörg Marusczyk, ONTOX partner MN-AM chief technology officer, the developer and maintainer of the ONTOX Hub and marketplace
  – booth #530

16-18 November – Congreso SEBiBC  – Valencia, Spain

Presentation:

• DockTox: A molecular docking platform for screening small molecules targeting Molecular Initiating Events (MIEs) relevant to liver, kidney and brain adverse events
  – presenter: Ortega-Vallbona R. (ProtoQSAR)

25-29 November – OpenTox Virtual Conference 2024 – online

Presentation:

• PBPK model-based QIVIVE to translate AOP-informed in vitro test battery data in NGRA
  – presenter: Kramer N. (WUR)
• Building Adverse Outcome Pathways with the help of AI
  – presenter: Teunis M. (HU)

23-27 October – American Society of Nephrology | Kidney week – San Diego, California

Poster:

• Simulating kidney proximal tubular crystallopathy in vitro
  – presenter:  R. Masereeuw (Utrecht University)

4-6 September – VPH 2024 Conference – Stuttgart, Germany

PRESENTATIONs:

3-6 June – The 22nd International Congress of the European Society of Toxicology In Vitro (ESTIV 2024) – Prague, Czech Republic

PRESENTATIONs and posters:

• ASPIS Academy and the Early-Stage Researchers’ transformative potential in toxicology
  – presenter: Ladeira L. (Université de Liège)
• A stem cell-based in vitro test battery to predict liver steatotic potential of diverse chemicals
  – presenter: Verhoeven A. (Vrije Universiteit Brussel)
• Mapping Physiology As A Basis For Building Disease Ontology Maps
  – presenter: Staumont B. (Université de Liège)

7-10 April – 5th INTERNATIONAL CONFERENCE ON DEVELOPMENTAL NEUROTOXICITY TESTING (DNT5) – Konstanz, Germany

PRESENTATIONs and posters:

• Neurodevelopmental effects of noradrenergic receptor agonists in human induced neural progenitor cells (hiNPCs) undergoing differentiation
  – presenter: Lislien M. (Norwegian Institute of Public Health)
• Ontology-based AI-driven innovative approach using DNT in vitro NAMs for next generation risk assessment
  – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
• PFAS and Their Mixtures as Risk Factors for Neurodevelopmental Disorders Based on NAM and Epidemiological Studies
  – presenter: Myhre O. (Norwegian Institute of Public Health)
• The DNT In-Vitro Testing Battery Project
  – presenter: Fritsche E. (Leibniz Research Institute for Environmental Medicine)
• Towards a Virtual Embryo: Computational Modelling of Neural Tube Closure Defects
  – presenter: Heusinkveld H. (National Institute for Public Health and the Environment RIVM)

10-14 March 2024 – SOT 63rd Annual Meeting & ToxExpo – Salt Lake City, Utah, USA

POSTERS:

• Learning by Doing Modelling and Simulation for Risk Assessment in the Open-Source Open Systems Pharmacology Suite (PK-Sim® and MoBi®)
  – presenter: Schaller S. (esqLABS GmbH)
  – poster number P364, Session Date: 11 March 2024, 2:15 PM-4:15 PM
• New approach to study chemicals toxicities in the kidney based on the physiological map and ontologies 
  – presenter: Gamba A. (Université de Liège),
  – poster number P124, Session Date: 13 March 2024, 2:15 PM-4:15 PM
• Systems modelling of quantitative adverse outcome pathways: progress on the integration of toxicokinetics and beyond
  – presenter: Yang H. (esqLABS GmbH)
  – poster number P211, Session Date: 13 March 2024, 2:15 PM-4:15 PM

PRESENTATIONS:

• SCREENED: Screening for the Influence of Endocrine Disruptors on the Male and Female Thyroid Gland
  – presenter: Caiment F. (Maastricht University)
  – Session Date: 11 March 2024, 2:20 PM-2:50 PM
• SCREENED: The Developmental Neurotoxicity In Vitro Battery: The New Kid on the Block in the Regulatory Arena
  – presenter: Fritsche E. (IUF – Leibniz Research Institute for Environmental Medicine)
  – Session Date: 11 March 2024, 2:15 PM-2:40 PM
• ToxAIcology-AI Will Only Replace Toxicologists Who Do Not Use It!
  – presenter: Hartung T. (JHU – Johns Hopkins University)
  – Session Date: 11 March 2024, 12:00 PM-1:30 PM
• Adapting models of in vitro distribution kinetics for Next Generation Risk Assessment of developmental neurotoxicity
  – presenter: Proenca S. (esqLABS GmbH)
  – Session Date: 12 March 2024, 3:25 PM-3:45 PM
• Physiological Maps as a Tool for Knowledge Integration and Sharing through FAIR-Aligned Structures
  – presenter: Staumont B. (Université de Liège)
  – Session Date: 12 March 2024, 3:40 PM-3:55 PM
• Probabilistic Approaches to Hazard and Risk Assessment
  – presenter: Hartung T. (JHU – Johns Hopkins University)
  – Session Date: 13 March 2024, 9:45 AM-10:15 AM
• Human Disease-Relevant Signaling Pathways as Reference Points for Gaining Certainty in Developmental Neurotoxicity New Approach Methodologies
  – presenter: Fritsche E. (IUF – Leibniz Research Institute for Environmental Medicine)
  – Session Date: 14 March 2024, 10:35 AM-11:05 AM

26-29 January – NSFT Winter meeting (Norwegian Society of pharmacology and toxicology) – Beitostølen, Norway

Presentation:

• Transcriptomic characterization of 2D and 3D human induced pluripotent stem cell based in vitro New Approach Methodologies (NAMs) for developmental neurotoxicity testing
  – presenter: Lislien M. (Norwegian Institute of Public Health)

9-10 November – 2nd F2F-MEETING OF THE LEIBNIZ RESEARCH NETWORK ‘STEM CELLS AND ORGANOIDS‘ – Düsseldorf, Germany

Poster:

• Mapping the Brain Physiological Maze: innovative tool for advancing developmental neurotoxicology
  – presenter: Polozij D. (IUF – Leibniz Research Institute for Environmental Medicine)

5-6 October – 5TH MEETING OF TRANSLATIONAL HEPATOLOGY – Seville, Spain

PRESENTATION:

• Novel clinical phenotypes in cholestatic DILI, associated drugs, and new prognosis predictive models: analysis of a database of 432 patients developed by collaborative literature review and machine learning support
  – presenter: Lopez-Pascual E. (Universitat de Valencia)

19-21 September – JOINT 3R SYMPOSIUM – Brussels, Belgium

PRESENTATIONS:

• Introduction to life stage-dependent neurotoxicity, including current status of AOPs
  – presenter: Myhre O. (Norwegian Institute of Public Health)
• Neurodevelopmental toxicity in the European H2020 ONTOX project
  – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)

14-15 September – ASPIS OPEN SYMPOSIUM 2023 – Ljubljana, Slovenia

The ASPIS Open Symposium followed the 57th Congress of the European Societies of Toxicology, EUROTOX. It presented the latest work of the ASPIS cluster formed by the three Horizon 2020 consortia: ONTOX, PrecisionTox, and RISK-HUNT3R, focusing on the implementation of New Approach Methodologies (NAMs) for chemical risk assessment.

10-14 SEPTEMBER – DIOXIN 2023 – MAASTRICHT, THE NETHERLANDS

POSTER:

• Comparison of exposure to PFOS from diet and personal care products with concentrations in blood using a PBPK model – Preliminary results from the EuroMix study as part of the EU project ONTOX
  – presenter: Husøy T. (Folkehelseinstituttet)

10-13 September – EUROTOX CONGRESS 2023 – Ljubljana, Slovenia

PRESENTATIONS AND POSTERS:

• ASPIS omics group – Steatosis case study
  – presenter: Verheijen M. (Universiteit Maastricht)
• Going the extra mile for NAM acceptance; Engaging stakeholders for next generation risk assessment
  – presenter: Diemar M. G. (3Rs Management and Consulting ApS)
• Mapping of DNT NAMs’ signaling pathways in human physiology and disease for regulatory application
  – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
• Next Generation PBK modeling with PK-Sim for the prediction of chemical distribution in humans
  – presenter: Geci R. (esqLABS GmbH)
• Novel clinical phenotypes and chemical classifications in drug-induced cholestasis: analysis of a database of 390 patients developed by collaborative literature review and machine learning support
  – presenter: Lopez-Pascual E. (Universitat de Valencia)
• Online methods and tools for assessing chemical exposure in humans: a systematic scoping review for the ONTOX project
  – presenter: Kalyva M. (Folkehelseinstituttet)
• ONTOX Hub Meta Database paving the way for integrated use of New Approach Methodologies in Next Generation Risk Assessment
  – presenter: Mostrag A. (Molecular Networks GmbH)
• Probabilistic read-across assessment of 2-MCPD leveraging machine learning and qualified data
  – presenter: Rathman J. (Molecular Networks GmbH)
• The cognitive function defects ontology: A comprehensive framework for Next-Generation Risk Assessment
  – presenter: Ladeira L. (Université de Liège)
• The nephron physiological map as a tool to build kidney disease ontologies
  – presenter: Gamba A. (Université de Liège)
• Towards a virtual embryo: Computational modelling of neural tube closure defects
  – presenter: Berkhout J. (Universiteit Utrecht)

27-31 August – WORLD CONGRESS ON ALTERNATIVES AND ANIMAL USE IN THE LIFE SCIENCES WC12 – Niagara Falls, Canada

PRESENTATIONS:

• • Bringing reproducible research and programming skills to the large international research consortium ONTOX; think big – act small
    – presenter: Teunis M. (Hogeschool Utrecht)
  • Going the extra mile for NAM acceptance; Engaging stakeholders for next generation  risk assessment
    – presenter: Krul C. (Hogeschool Utrecht)
  • Mapping of DNT NAMs’ signaling pathways in human physiology and disease
    – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
  • Systems-Biology Modelling of Steatosis and Uncertainty Quantification Towards NGRA
    – presenter: Yang H. (esqLABS GmbH)
  • Towards regulatory acceptance of qAOP-based NGRA through integration with a qualified open-source PBK framework
    – presenter: Schaller S. (esqLABS GmbH)

POSTERS:

• • An adverse outcome pathway network for liver steatosis induced by chemicals
    – presenter: Verhoeven A. (Vrije Universiteit Brussel)
  • Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis
    – presenter: Jian J. (Vrije Universiteit Brussel)
  • Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
    – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

13-17 August – ACS FALL 2023 – San Francisco, USA

PRESENTATION:

• Predicting the mitochondrial toxicity of small molecules: Insights from mechanistic assays and cell painting data
  – presenter: Garcia de Lomana M. (Bayer)
•  

19-21 June – INTERNATIONAL CONFERENCE ON SYSTEMS BIOLOGY OF HUMAN DISEASE – Berlin, Germany

Poster:

• From nephron physiological map to kidney disease ontologies: a systems biology approach for in silico toxicology
  – presenter: Gamba A. (Université de Liège)

7-8 June – NVT ANNUAL MEETING 2023 – Ede, The Netherlands

POSTER:

• • Towards a virtual embryo: Computational modelling of neural tube closure defects
    – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)

31-May-1 June – NEW APPROACH METHODOLOGIES WORKSHOP: TOWARDS AN ANIMAL FREE REGULATORY SYSTEM FOR INDUSTRIAL CHEMICALS – Helsinki, Finland

Presentations:

• Short perspectives on current status and short- to long-term opportunities – Carcinogenity
  – Heusinkveld H. (National Institute for Public Health and the Environment RIVM)
• Short perspectives on current status and short- to long-term opportunities – Developmental and Reproductive Toxicity
  – Piersma A. (National Institute for Public Health and the Environment RIVM)

23-26 May – JRC SUMMER SCHOOL ON NON-ANIMAL APPROACHES IN SCIENCE – Ispra, Italy – ISPRA, ITALY

POSTERS:

• • Next Generation PBK modelling with PK-Sim for the prediction of chemicals distribution in humans
    – presenter: Geci R. (esqLABS GmbH)
  • Physiological maps as a non-animal approach for next-generation risk assessment
    – presenter: Gamba A. (Université de Liège)
  • Update and optimization of an Adverse Outcome Pathway Network of chemical induced cholestasis
    – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

19-23 March – SOT 62nd ANNUAL MEETING AND TOXEXPO – Nashville, USA

Posters:

• A mechanistic and probabilistic PBPK model for amiodarone for quantitative in vitro to in vivo extrapolation
  – presenter: Proença S. (Wageningen University & Research)
• Computational modelling of neural tube closure defects
  – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
• ONTOX Hub meta database bridging AI-based NAMs for Next Generation Risk Assessment 
  – presenter: Mostrag-Szlichtyng A. (Molecular Networks GmbH)

13-14 MARCH – STAKEHOLDER NETWORK MEETING – BRUSSELS, BELGIUM

This first ONTOX Stakeholder meeting, titled “Digging under the surface of ONTOX“, prioritised and addressed specific challenges for the planned Hackathon event (end of 2023/beginning of 2024). The Stakeholder Network meeting was by invitation only.

24-25 NOVEMBER – ASPIS 2nd OPEN SYMPOSIUM – SITGES, SPAIN

Posters:

• A joint voice on the side of NAMs-based strategies for chemical risk assessment: Communication activities 
  – presenter: Kandarova H. and Milec L. (Centre of Experimental Medicine)
• An adverse outcome pathway network for liver steatosis induced by chemicals
  – presenter: Verhoeven A. (Vrije Universiteit Brussel)
• ASPIS Omics Working Group
  – presenter: Caiment F. (Maastricht University)
• Computational modelling of neural tube closure defects
  – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
• Development of an adverse outcome pathway for kidney tubular necrosis
  – presenter: Barnes D. (Universiteit Utrecht)
• Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and pharmacokinetic data gaps within the ONTOX project
  – presenter: Ortega R. (ProtoQSAR)
• In vitro New Approach Methodologies (NAMs) for assessing effects of chemicals leading to cognitive function defects in children – the contributions of the ONTOX project
  – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)
• Kinetic modelling and quantitative in vitro-in vivo extrapolation strategies for next generation risk assessment in the H2020 ONTOX project
  – presenter: Geci R. (esqLABS GmbH)
• Physiological maps and chemical-induced disease ontologies: tools to support NAMs development for next-generation risk assessment
  – presenter: Ladeira L. C. M. and Gamba A. (Université de Liège)
• Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis
  – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

21-25 November – 21st INTERNATIONAL CONGRESS OF THE ESTIV – Sitges, Spain

PRESENTATION:

• First steps for creating an ontology for cognitive function defects for regulatory application
  – presenter: Kuchovska E. (Leibniz Research Institute for Environmental Medicine)

POSTERS:

• An adverse outcome pathway network for liver steatosis induced by chemicals 
  – presenter: Verhoeven A.(Vrije Universiteit Brussel)
• Applying machine-learning approaches to identify key genes associated with drug-induced cholestasis 
  – presenter: Jiang J. (Vrije Universiteit Brussel)
• Computational modelling of neural tube closure defects
  – presenter: Berkhout J. (National Institute for Public Health and the Environment RIVM)
• Designing physiological maps as a tool to study liver toxicology
  – presenter: Ladeira L. C. M. (Université de Liège)
• Development of an adverse outcome pathway for kidney tubular necrosis 
  – presenter: Barnes D. (Universiteit Utrecht)
• Evaluation of state-of-the-art in silico testing methods to fill physico-chemical and toxicokinetic data gaps within the ONTOX project 
  – presenter: Roncaglioni A. (Istituto di Ricerche Farmacologiche Mario Negri)
• Facilitating modern toxicology with natural language processing
  – presenter: Corradi M. (Hogeschool Utrecht)
• PBK modelling of in vivo distribution kinetics in the ONTOX project 
  – presenter: Geci R. (esqLABS GmbH)
• Physiological map to study kidney toxicity in the ONTOX project 
  – presenter: Gamba A. (Université de Liège)
• Update and optimization of an adverse outcome pathway network of chemical-induced cholestasis 
  – presenter: van Ertvelde J. (Vrije Universiteit Brussel)

18-19 October – ECETOC WORKSHOP ON QUANTITATIVE RESPONSE – RESPONSE RELATIONSHIPS (qAOPs) – Brussels, Belgium

presentation:

• Quantitative systems modeling of qAOP and its data integration – ONTOX perspective
  – presenters: Yang H. (esqLABS GmbH)

14-16 October – I LOVE SCIENCE FESTIVAL – Brussels, Belgium

BOOTH:

• Animal-free labs
  – presenters: Belot N., Boige A., Busquet F., Salamone V. (Altertox)

30 SEPTEMBER – The European Researchers’ Night 2022 – Bratislava, Slovakia

BOOTH:

• Toxicology of the 21st century
  – presenters: Kandarova H., Milec L., Pobis P. (Centre of experimental medicine of the Slovak Academy of Sciences) 

29 SEPTEMBER – 3rd In Silico Toxicology Conference 2022 – online

PRESENTATION:

• The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

26-28 SEPTEMBER – The 2022 European Congress on Alternatives to Animal Testing – linz, austria

PRESENTATION:

• The European ONTOX project: safer chemicals using less animals
  – presenter: Vinken M. (Vrije Universiteit Brussel)

22 September – HEARING FLEMISH PARLIAMENT – Virtual

PRESENTATION:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

18-21 September – XVI INTERNATIONAL CONGRESS OF TOXICOLOGY – Maastricht, The Netherlands

12-16 September – EMBL-EBI TRAINING: MATHEMATICS OF LIFE: MODELLING MOLECULAR MECHANISMS – Virtual

6-9 September – VPH 2022 CONFERENCE: VIRTUAL PHYSIOLOGICAL HUMAN – Porto, Portugal

PosterS:

• Developing a physiological map as a framework to study chemical-induced liver steatosis
  – presenter:  Ladeira L. C. M. (Université de Liège)
• From physiological map to ontology unravelling kidney toxicity
  – presenter: Gamba A. (Université de Liège)
• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
• – presenter: Vinken M. (Vrije Universiteit Brussel)

29-30 June – FACE MEETING OF THE LEIBNIZ RESEARCH NETWORK “STEM CELLS AND ORGANOIDS” – Düsseldorf, Germany

Poster:

• First steps for creating an ontology for cognitive function defects for regulatory application
  – presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine)

21-24 June – ONE CONFERENCE 2022 – Brussels, Belgium/Virtual

Posters:

• First steps for creating an ontology for cognitive function deficits for regulatory application
  – presenter: Kuchovska E. (IUF – Leibniz Research Institute for Environmental Medicine)
• Research activities on kinetic modelling and quantitative in vitro–in vivo extrapolation for next generation risk assessment in the H2020 ONTOX project
  – presenter: Paini A. (esqLABS GmbH)
• Use of the Open-Source Software Open Systems Pharmacology Suite (PK-Sim® and MoBi®) in Next Generation Risk Assessment (NGRA)
  – presenter: Schaller S. (esqLABS GmbH)

13-17 JUNE – SUMMER SCHOOL IN BIOINFORMATICS – Hinxton, United Kingdom

Poster:

• From human physiology to toxicity prediction: Working on the ONTOX project
  – presenter: Ladeira L. C. M. (Université de Liège)

27-31 March – The Society of Toxicology 61st Annual Meeting and ToxExpo – USA

Presentation:

• Assessment of Human Neuronal Network Formation and Function Using 2D and 3D hiPSC-Derived Cell Systems
  – presenter: Fritsche E. (IUF – Leibniz Research Institute for Environmental Medicine)
• Computational modeling of (sub)cellular key events in quantitative adverse outcome pathways  towards model-informed human health risk assessment
  – presenter: Schaller S. (esqLABS GmbH)
• Human Neural Tube Defects: Basic Embryology to Predictive Toxicology
  – presenter: Heusinkveld H. (National Institute for Public Health and the Environment RIVM)

14 February – EFSA info session: animal-free next generation risk assessment ready by 2026 – Belgium

Presentation:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

26 January – OECD Working Party on Hazard Assessment – virtual

Presentation:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

18 November – Second international Conference on 3R’S Research and progress – virtual

10 November – The Gates Foundation Grand Challenge meeting – virtual

4 November – ASPIS Kick Off Meeting – Belgium

Presentation:

• ONTOX: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

22 OCTOBER – Closing event PLANT-UPmeeting – virtual

PRESENTATION:

• 3Rs in EU Policy and Research
  – presenter: Busquet F. (Altertox)

5 October – ILSI Europe annual symposium – The Netherlands

Presentation:

• The European ONTOX project: ontology-driven and artificial intelligence-based repeated dose toxicity testing of chemicals for next generation risk assessment
  – presenter: Vinken M. (Vrije Universiteit Brussel)

29 September – EUROTOX – virtual

Presentation:

• Development and application of an adverse outcome pathway of cholestatic liver injury
  – presenter: Vinken M. (Vrije Universiteit Brussel)