NAMs solutions for EPAA
Explore NAMs-based solutions created by ONTOX for the EPAA designathon for human systemic toxicity
About The designathon
Towards an animal free regulatory system for industrial chemicals
On 31 May, the ‘New approach methodologies (NAMS) workshop: Towards an animal free regulatory system for industrial chemicals’ took place at the European Chemicals Agency (ECHA) in Helsinki.
During this workshop, the European Partnership for Alternative Approaches to Animal Testing (EPAA) launched its designathon for human systemic toxicity.
The designathon challenge was to propose prototype NAM-based solutions for discussion at a workshop. These solutions should have been dedicated to informing the development of a potential future classification system for human systemic toxicity.
ONTOx CONTRIBUTIONS
ONTOX researchers produced 6 solutions for the designathon, aiming to move towards an animal-free regulatory system. ONTOX solutions are presented in the posters below.
NTEGRATED COMPUTATIONAL NAM BASED ON MOLECULAR INITIATING EVENTS (MIES) AND PBK PREDICTIONS FOR EVALUATION OF THE STEATOGENIC POTENTIAL OF CHEMICALS
NAM TO IDENTIFY (LOW, MEDIUM, HIGH) CONCERN OF CARBOXYLIC ACID-INDUCED HEPATIC STEATOSIS
ONTOX HT-PBK: High-throughput PBK modelling for the in silico prediction of chemical levels in humans
Authors: Domenico Gadaleta, Marina García De Lomana, René Geci, Rafael Gozalbes, Davide Luciani, Rita Ortega Vallbona, Alicia Paini, Susana Proença, Alessandra Roncaglioni, Eva Serrano Candelas, Emilio Benfenati
Authors: Ramiro Jover, Polina Soluyanova, Marta del Pozo, Anouk Verhoeven, Tamara Vanhaecke, Mathieu Vinken, Rita Ortega Vallbona, Eva Serrano Candelas, Rafael Gozalbes, René Geci, Susana Proença
Authors: René Geci, Susana Proença, Alicia Paini, Lars Küpfer, Stephan Schaller
PKMine; AI for extracting input parameters from different sources to support PBK modelling
Test battery for the detection of induction of molecular initiating events of cholestatic liver toxicity induced by chemical compounds
Transcriptomics Acute Model: A concept for general profiling of acute tissue specific chemical responses
Authors: Marc Teunis, Marie Corradi, Ivo Djidrovski, Susana Proença, Huan Yang, Thomas Luechtefeld, Thomas Hartung, Nynke Kramer
Authors: Julen Sanz-Serrano, Emilio Benfenati, Annika Drees, Domenico Gadaleta, Marina García de Lomana, René Geci, Rafael Gozalbes, Nynke Kramer, Amy Maertens, Rita Ortega Vallbona, Alicia Paini, Susana Proença, Eva Serrano Candelas, Anouk Verhoeven, Mathieu Vinken
Authors: Marcha Verheijen, Brian Bwanya, Florian Caiment
Briefing webinar
Before the designation, EPAA presented the event’s aim in the short webinar, including an introduction to the NAMs project. The recording is available below.
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